PSM: Non-Linear Mixed-Effects modelling using Stochastic Differential Equations

This package provides functions for estimation of linear and non-linear mixed-effects models using stochastic differential equations. Moreover it provides functions for finding smoothed estimates of model states and for simulation. The package allows for any multivariate non-linear time-variant model to be specified, and it also handles multidimensional input, co-variates, missing observations and specification of dosage regimen.

Version: 0.8-10
Depends: MASS, numDeriv, deSolve, ucminf
Published: 2013-09-10
Author: Stig Bousgaard Mortensen and Søren Klim
Maintainer: Stig Bousgaard Mortensen <stigbm at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
In views: DifferentialEquations
CRAN checks: PSM results


Reference manual: PSM.pdf
Vignettes: Population Stochastic Modelling: Model definition, description and examples
Package source: PSM_0.8-10.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Snow Leopard binaries: r-release: PSM_0.8-10.tgz, r-oldrel: PSM_0.8-10.tgz
OS X Mavericks binaries: r-release: PSM_0.8-10.tgz
Old sources: PSM archive