JAGUAR

This is an R-package to implement a novel score test method to map group-specific eQTL that tests for the main genotypic effect and variability among tissues in a mixed effects model framework. Modeling the tissue-specificity as a random effect and the additive genotypic effect as a fixed effect results in a two degree-of-freedom test that avoids measuring multiple parameters due to higher number of tissues thus enhancing power. This approach implicitly assumes that the effect of a SNP on gene expression could be in different directions in different tissues.

This package is free software, you can redistribute it and/or modify it under the terms of the GNU General Public License.The GNU General Public License does not permit this software to be redistributed in proprietary programs. We are providing no guarantees with this software.