## VCA: Variance Component Analysis

ANOVA-type estimation (prediction) of random effects in linear mixed models is implemented, following
Searle et al. 1991 (ANOVA for unbalanced data). For better performance the SWEEP-Operator is now implemented
for generating the ANOVA Type-1 error sum of squares. The primary objective of this package is to perform
Variance Component Analyses (VCA). This is a special type of analysis frequently used in verifying the
precision performance of diagnostics.
The Satterthwaite approximation of the total degrees of freedom and for individual variance components is
implemented. These are used in the Chi-Squared tests against a claimed value, and in the respective confidence intervals.
Satterthwaite's approximation of denominator degrees of freedom in t-/F-tests of fixed effects are also
available.
There are several functions for extracting, random effects, fixed effects, variance-covariance
matrices of random and fixed effects. Residuals (marginal, conditional) can be extracted as raw, standardized
and studentized residuals.
Additionally, plotting methods for residuals and random effects and a variability chart are available. The latter
is useful for visualizing the variability in sub-classes emerging from the experimental design.

Version: |
1.2 |

Depends: |
R (≥ 3.0.0) |

Imports: |
stats, graphics, grDevices, Matrix, methods, numDeriv |

Published: |
2015-07-20 |

Author: |
Andre Schuetzenmeister |

Maintainer: |
Andre Schuetzenmeister <andre.schuetzenmeister at roche.com> |

License: |
GPL (≥ 3) |

NeedsCompilation: |
yes |

CRAN checks: |
VCA results |

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