FamEvent: Simulation of Time-to-Event Family Data and Penetrance Estimation

Generates time-to-event family data associated with mutated genes arising from various family study designs such as population-based, clinic- based, or multi-stage designs and provides functions to fit family data accounting for the study design and estimate age-dependent penetrance functions. It also provides carrier probabilities for those with missing genotypes and penetrance estimations are based on an Expectation-Maximization algorithm when genotypes are missing.

Version: 1.0
Depends: R (≥ 3.0.0), base, MASS, truncnorm, survival, kinship2
Published: 2016-02-09
Author: Yun-Hee Choi, Karen Kopciuk, Wenqing He, Laurent Briollais
Maintainer: Yun-Hee Choi <yun-hee.choi at schulich.uwo.ca>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2.0)]
NeedsCompilation: no
CRAN checks: FamEvent results


Reference manual: FamEvent.pdf
Package source: FamEvent_1.0.tar.gz
Windows binaries: r-devel: FamEvent_1.0.zip, r-release: FamEvent_1.0.zip, r-oldrel: FamEvent_1.0.zip
OS X Snow Leopard binaries: r-release: FamEvent_1.0.tgz, r-oldrel: not available
OS X Mavericks binaries: r-release: FamEvent_1.0.tgz