cardioModel: Cardiovascular Safety Exposure-Response Modeling in Early-Phase Clinical Studies

Includes 100 mixed-effects model structures describing the relationship between drug concentration and QT interval, heart rate/pulse rate or blood pressure. Given an exposure-response dataset, the tool fits each model structure to the observed data.

Version: 1.3
Depends: R (≥ 2.10.0)
Imports: nlme, lubridate
Published: 2016-02-10
Author: Daniela J Conrado [aut, cre], Gregory J Hather [aut], William S Denney [aut], Danny Chen [ctb]
Maintainer: Daniela J Conrado <danielac at>
License: GPL-3
NeedsCompilation: no
Citation: cardioModel citation info
CRAN checks: cardioModel results


Reference manual: cardioModel.pdf
Package source: cardioModel_1.3.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Snow Leopard binaries: r-release: cardioModel_1.3.tgz, r-oldrel: not available
OS X Mavericks binaries: r-release: cardioModel_1.3.tgz
Old sources: cardioModel archive