Optimized DMR analysis based on bimodal normal distribution model and cost function for regional methylation analysis optimization. It captures the regional methylation modification by taking the spatial distribution of CpGs into account for the enrichment DNA methylation sequencing data so as to optimize the definition of the empirical regions. Combined with the dependent adjustment for regional p-value combination and DMR annotation.
| Version: | 0.6.3.1 |
| Depends: | R (≥ 3.2.1) |
| Imports: | GenomicRanges, IRanges, data.table, mixtools, S4Vectors |
| Published: | 2015-07-09 |
| Author: | Sheng Li [aut, cre, cph], Francine Garrett-Bakelman [ctb], Altuna Akalin [ctb], Paul Zumbo [ctb], Ari Melnick [ctb], Chris Mason [ctb, ths] |
| Maintainer: | Sheng Li <shelly1436 at gmail.com> |
| License: | Artistic-2.0 |
| URL: | https://github.com/ShengLi/edmr |
| NeedsCompilation: | no |
| Citation: | edmr citation info |
| Materials: | README |
| CRAN checks: | edmr results |
| Reference manual: | edmr.pdf |
| Package source: | edmr_0.6.3.1.tar.gz |
| Windows binaries: | r-devel: edmr_0.6.3.1.zip, r-release: edmr_0.6.3.1.zip, r-oldrel: not available |
| OS X Snow Leopard binaries: | r-release: not available, r-oldrel: not available |
| OS X Mavericks binaries: | r-release: edmr_0.6.3.1.tgz |
| Old sources: | edmr archive |