PSM: Non-Linear Mixed-Effects modelling using Stochastic Differential
Equations
This package provides functions for estimation of linear
and non-linear mixed-effects models using stochastic
differential equations. Moreover it provides functions for
finding smoothed estimates of model states and for simulation.
The package allows for any multivariate non-linear time-variant
model to be specified, and it also handles multidimensional
input, co-variates, missing observations and specification of
dosage regimen.
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