RefFreeEWAS: EWAS using Reference-Free DNA Methylation Mixture Deconvolution

Reference-free method for conducting EWAS while deconvoluting DNA methylation arising as mixtures of cell types. The older method (Houseman et al., 2014) is similar to surrogate variable analysis (SVA and ISVA), except that it makes additional use of a biological mixture assumption. The newer method (Houseman et al., 2016) is similar to non-negative matrix factorization, with additional constraints and additional utilities.

Version: 2.0
Depends: R (≥ 3.2.2), isva, quadprog
Published: 2016-01-30
Author: E. Andres Houseman, Sc.D.
Maintainer: E. Andres Houseman <andres.houseman at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: RefFreeEWAS results


Reference manual: RefFreeEWAS.pdf
Package source: RefFreeEWAS_2.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Mavericks binaries: r-release: RefFreeEWAS_2.0.tgz, r-oldrel: RefFreeEWAS_2.0.tgz
Old sources: RefFreeEWAS archive


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