httk: High-Throughput Toxicokinetics

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

Version: 1.4
Depends: R (≥ 2.10)
Imports: deSolve, msm
Suggests: ggplot2
Published: 2016-02-03
Author: John Wambaugh and Robert Pearce, Schmitt method implementation by Jimena Davis, dynamic model adapted from code by R. Woodrow Setzer, Rabbit parameters from Nisha Sipes
Maintainer: John Wambaugh <wambaugh.john at epa.gov>
License: GPL-3
NeedsCompilation: yes
CRAN checks: httk results

Downloads:

Reference manual: httk.pdf
Package source: httk_1.4.tar.gz
Windows binaries: r-devel: httk_1.4.zip, r-release: httk_1.4.zip, r-oldrel: httk_1.4.zip
OS X Mavericks binaries: r-release: httk_1.4.tgz, r-oldrel: httk_1.4.tgz
Old sources: httk archive

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