Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objectives are to determine the maximum tolerated dose (MTD) and to investigate the pharmacokinetics of a drug or a combination of drugs.
| Version: | 2.0.0 |
| Depends: | R (≥ 3.0.2), Rcpp (≥ 0.12.0) |
| Imports: | rstan (≥ 2.12.1), ggplot2 (≥ 2.0.0), dfcrm, methods, stats, graphics, grDevices |
| LinkingTo: | StanHeaders (≥ 2.12.0), rstan (≥ 2.12.1), BH (≥ 1.60), Rcpp (≥ 0.12.0), RcppEigen |
| Published: | 2016-12-15 |
| Author: | Artemis Toumazi , Moreno Ursino and Sarah Zohar |
| Maintainer: | Artemis Toumazi <artemis.toumazi at inserm.fr> |
| BugReports: | http://github.com/artemis-toumazi/dfpk/issues |
| License: | GPL (≥ 3) |
| URL: | http://github.com/artemis-toumazi/dfpk |
| NeedsCompilation: | yes |
| Materials: | README |
| In views: | ExperimentalDesign |
| CRAN checks: | dfpk results |
| Reference manual: | dfpk.pdf |
| Package source: | dfpk_2.0.0.tar.gz |
| Windows binaries: | r-devel: dfpk_2.0.0.zip, r-release: dfpk_2.0.0.zip, r-oldrel: dfpk_2.0.0.zip |
| OS X Mavericks binaries: | r-release: dfpk_2.0.0.tgz, r-oldrel: dfpk_2.0.0.tgz |
| Old sources: | dfpk archive |
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