BIGDAWG: Case-Control Analysis of Multi-Allelic Loci

Data sets and functions for chi-squared Hardy-Weinberg and case-control association tests of highly polymorphic genetic data [e.g., human leukocyte antigen (HLA) data]. Performs association tests at multiple levels of polymorphism (haplotype, locus and HLA amino-acids) as described in Pappas DJ, Marin W, Hollenbach JA, Mack SJ (2016) <doi:10.1016/j.humimm.2015.12.006>. Combines rare variants to a common class to account for sparse cells in tables as described by Hollenbach JA, Mack SJ, Thomson G, Gourraud PA (2012) <doi:10.1007/978-1-61779-842-9_14>.

Version: 1.5.5
Depends: R (≥ 3.2.0)
Imports: XML, haplo.stats, parallel
Suggests: knitr, rmarkdown
Published: 2016-08-31
Author: Derek Pappas, Steve Mack, Jill Hollenbach
Maintainer: Steve Mack <sjmack at>
License: GPL (≥ 3)
NeedsCompilation: no
Materials: NEWS
CRAN checks: BIGDAWG results


Reference manual: BIGDAWG.pdf
Vignettes: Using BIGDAWG
Package source: BIGDAWG_1.5.5.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Mavericks binaries: r-release: BIGDAWG_1.5.5.tgz, r-oldrel: BIGDAWG_1.5.5.tgz
Old sources: BIGDAWG archive


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