Addition of the Fixed-sequence procedure (FixedSeqAdj, see Analysis model).
Addition of the Cox method to calculate the HR, effect size and ratio of effect size for time-to-event endpoint. This can be accomplished by setting the method argument in the parameter list to set-up the calculation based on the Cox method. (par = parameters(method = "Cox"), see Analysis model).
Revision of one-sided p-value computation for Log-Rank test.
Revision of the call for Statistic in the core function (not visible).
Revision of the function to calculate the Hazard Ratio Statistic (HazardRatioStat method). By default, this calculation is now based on the log-rank statistic ((O2/E2)/(O1/E1) where O and E are Observed and Expected event in sample 2 and sample 1. A parameter can be added using the method argument in the parameter list to set-up the calculation based on the Cox method (par = parameters(method = "Cox"), see Analysis model).
Revision of the function to calculate the effect size for time-to-event endpoint (EffectSizeEventStat method, based on the HazardRatioStat method)
Revision of the functions to calculate the ratio of effect size for continuous (RatioEffectSizeContStat method), binary (RatioEffectSizePropStat method) and event (RatioEffectSizeEventStat method) endpoint.
Revision of the function to generate the Test, Statistic, Design and result tables in the report.
Addition of the Beta distribution (BetaDist, see Data model).
Addition of the Truncated exponential distribution, which could be used as enrollment distribution (TruncatedExpoDist, see Data model).
Addition of the Non-inferiority test for proportion (PropTestNI, see Analysis model).
Addition of the mixture-based gatekeeping procedure (MixtureGatekeepingAdj see Analysis model).
Addition of a function to get the data generated in the CSE using the DataStack function (see Data stack).
Addition of a function to extract a specific set of data in a DataStack object (see Data stack).
Addition of the "Evaluation Model" section in the generated report describing the criteria and their parameters (see Simulation report).
Revision of the generation of dropout time.
Correction of the NormalParamAdj function.
Correction of the FisherTest function.