Methods Used for Dose-Aware Concentration Interpolation/Extrapolation

William Denney

Introduction

Interpolation and extrapolation with awareness of doses occurring before, at the same time of, or after the requested interpolation time point must account for many interactions. To ensure clarity in the interpolation/extrapolation methods and the decisions made by the algorithm, each potential choice is listed below with its accompanying calculation method. The code used to generate the table is the same as the code within the function.

Methods

The method list below is described and sorted in order of how many scenarios the method is applied to in the list.

For each of the summary tables below, the column headers are as follows:

Copy

Copy the input concentration at the given time to the output.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
NA NA both FALSE NA FALSE
NA NA both FALSE NA TRUE
NA NA both FALSE both FALSE
NA NA both FALSE both TRUE
NA NA both FALSE conc FALSE
NA NA both FALSE conc TRUE
NA NA both FALSE dose FALSE
NA NA both FALSE dose TRUE
NA NA both TRUE NA FALSE
NA NA both TRUE both FALSE
NA NA both TRUE conc FALSE
NA NA both TRUE dose FALSE
NA NA conc NA NA FALSE
NA NA conc NA NA TRUE
NA NA conc NA both FALSE
NA NA conc NA both TRUE
NA NA conc NA conc FALSE
NA NA conc NA conc TRUE
NA NA conc NA dose FALSE
NA NA conc NA dose TRUE
both FALSE both FALSE NA FALSE
both FALSE both FALSE NA TRUE
both FALSE both FALSE both FALSE
both FALSE both FALSE both TRUE
both FALSE both FALSE conc FALSE
both FALSE both FALSE conc TRUE
both FALSE both FALSE dose FALSE
both FALSE both FALSE dose TRUE
both FALSE both TRUE NA FALSE
both FALSE both TRUE both FALSE
both FALSE both TRUE conc FALSE
both FALSE both TRUE dose FALSE
both FALSE conc NA NA FALSE
both FALSE conc NA NA TRUE
both FALSE conc NA both FALSE
both FALSE conc NA both TRUE
both FALSE conc NA conc FALSE
both FALSE conc NA conc TRUE
both FALSE conc NA dose FALSE
both FALSE conc NA dose TRUE
both TRUE both FALSE NA FALSE
both TRUE both FALSE NA TRUE
both TRUE both FALSE both FALSE
both TRUE both FALSE both TRUE
both TRUE both FALSE conc FALSE
both TRUE both FALSE conc TRUE
both TRUE both FALSE dose FALSE
both TRUE both FALSE dose TRUE
both TRUE both TRUE NA FALSE
both TRUE both TRUE both FALSE
both TRUE both TRUE conc FALSE
both TRUE both TRUE dose FALSE
both TRUE conc NA NA FALSE
both TRUE conc NA NA TRUE
both TRUE conc NA both FALSE
both TRUE conc NA both TRUE
both TRUE conc NA conc FALSE
both TRUE conc NA conc TRUE
both TRUE conc NA dose FALSE
both TRUE conc NA dose TRUE
conc NA both FALSE NA FALSE
conc NA both FALSE NA TRUE
conc NA both FALSE both FALSE
conc NA both FALSE both TRUE
conc NA both FALSE conc FALSE
conc NA both FALSE conc TRUE
conc NA both FALSE dose FALSE
conc NA both FALSE dose TRUE
conc NA both TRUE NA FALSE
conc NA both TRUE both FALSE
conc NA both TRUE conc FALSE
conc NA both TRUE dose FALSE
conc NA conc NA NA FALSE
conc NA conc NA NA TRUE
conc NA conc NA both FALSE
conc NA conc NA both TRUE
conc NA conc NA conc FALSE
conc NA conc NA conc TRUE
conc NA conc NA dose FALSE
conc NA conc NA dose TRUE
dose FALSE both FALSE NA FALSE
dose FALSE both FALSE NA TRUE
dose FALSE both FALSE both FALSE
dose FALSE both FALSE both TRUE
dose FALSE both FALSE conc FALSE
dose FALSE both FALSE conc TRUE
dose FALSE both FALSE dose FALSE
dose FALSE both FALSE dose TRUE
dose FALSE both TRUE NA FALSE
dose FALSE both TRUE both FALSE
dose FALSE both TRUE conc FALSE
dose FALSE both TRUE dose FALSE
dose FALSE conc NA NA FALSE
dose FALSE conc NA NA TRUE
dose FALSE conc NA both FALSE
dose FALSE conc NA both TRUE
dose FALSE conc NA conc FALSE
dose FALSE conc NA conc TRUE
dose FALSE conc NA dose FALSE
dose FALSE conc NA dose TRUE
dose TRUE both FALSE NA FALSE
dose TRUE both FALSE NA TRUE
dose TRUE both FALSE both FALSE
dose TRUE both FALSE both TRUE
dose TRUE both FALSE conc FALSE
dose TRUE both FALSE conc TRUE
dose TRUE both FALSE dose FALSE
dose TRUE both FALSE dose TRUE
dose TRUE both TRUE NA FALSE
dose TRUE both TRUE both FALSE
dose TRUE both TRUE conc FALSE
dose TRUE both TRUE dose FALSE
dose TRUE conc NA NA FALSE
dose TRUE conc NA NA TRUE
dose TRUE conc NA both FALSE
dose TRUE conc NA both TRUE
dose TRUE conc NA conc FALSE
dose TRUE conc NA conc TRUE
dose TRUE conc NA dose FALSE
dose TRUE conc NA dose TRUE

Doses with no concentrations between

Two doses with no concentrations between them, return NA.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
both FALSE NA NA NA FALSE
both FALSE NA NA NA TRUE
both FALSE NA NA dose FALSE
both FALSE NA NA dose TRUE
both FALSE dose FALSE NA FALSE
both FALSE dose FALSE NA TRUE
both FALSE dose FALSE both FALSE
both FALSE dose FALSE both TRUE
both FALSE dose FALSE conc FALSE
both FALSE dose FALSE conc TRUE
both FALSE dose FALSE dose FALSE
both FALSE dose FALSE dose TRUE
both FALSE dose TRUE NA FALSE
both FALSE dose TRUE both FALSE
both FALSE dose TRUE conc FALSE
both FALSE dose TRUE dose FALSE
both TRUE dose FALSE NA FALSE
both TRUE dose FALSE NA TRUE
both TRUE dose FALSE both FALSE
both TRUE dose FALSE both TRUE
both TRUE dose FALSE conc FALSE
both TRUE dose FALSE conc TRUE
both TRUE dose FALSE dose FALSE
both TRUE dose FALSE dose TRUE
both TRUE dose TRUE NA FALSE
both TRUE dose TRUE both FALSE
both TRUE dose TRUE conc FALSE
both TRUE dose TRUE dose FALSE
dose FALSE NA NA NA FALSE
dose FALSE NA NA NA TRUE
dose FALSE NA NA both FALSE
dose FALSE NA NA both TRUE
dose FALSE NA NA dose FALSE
dose FALSE NA NA dose TRUE
dose FALSE dose FALSE NA FALSE
dose FALSE dose FALSE NA TRUE
dose FALSE dose FALSE both FALSE
dose FALSE dose FALSE both TRUE
dose FALSE dose FALSE conc FALSE
dose FALSE dose FALSE conc TRUE
dose FALSE dose FALSE dose FALSE
dose FALSE dose FALSE dose TRUE
dose FALSE dose TRUE NA FALSE
dose FALSE dose TRUE both FALSE
dose FALSE dose TRUE conc FALSE
dose FALSE dose TRUE dose FALSE
dose TRUE dose FALSE NA FALSE
dose TRUE dose FALSE NA TRUE
dose TRUE dose FALSE both FALSE
dose TRUE dose FALSE both TRUE
dose TRUE dose FALSE conc FALSE
dose TRUE dose FALSE conc TRUE
dose TRUE dose FALSE dose FALSE
dose TRUE dose FALSE dose TRUE
dose TRUE dose TRUE NA FALSE
dose TRUE dose TRUE both FALSE
dose TRUE dose TRUE conc FALSE
dose TRUE dose TRUE dose FALSE

Immediately after an IV bolus without a concentration next

Cannot calculate C0 without a concentration after an IV bolus; return NA.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
both FALSE both TRUE NA TRUE
both FALSE both TRUE both TRUE
both FALSE both TRUE dose TRUE
both FALSE dose TRUE NA TRUE
both FALSE dose TRUE both TRUE
both FALSE dose TRUE dose TRUE
both TRUE both TRUE NA TRUE
both TRUE both TRUE both TRUE
both TRUE both TRUE dose TRUE
both TRUE dose TRUE NA TRUE
both TRUE dose TRUE both TRUE
both TRUE dose TRUE dose TRUE
conc NA both TRUE NA TRUE
conc NA both TRUE both TRUE
conc NA both TRUE dose TRUE
conc NA dose TRUE NA TRUE
conc NA dose TRUE both TRUE
conc NA dose TRUE dose TRUE
dose FALSE both TRUE NA TRUE
dose FALSE both TRUE both TRUE
dose FALSE both TRUE dose TRUE
dose FALSE dose TRUE NA TRUE
dose FALSE dose TRUE both TRUE
dose FALSE dose TRUE dose TRUE
dose TRUE both TRUE NA TRUE
dose TRUE both TRUE both TRUE
dose TRUE both TRUE dose TRUE
dose TRUE dose TRUE NA TRUE
dose TRUE dose TRUE both TRUE
dose TRUE dose TRUE dose TRUE

Before all events

Interpolation before any events is NA or zero (0) depending on the value of conc.origin. conc.origin defaults to zero which is the implicit assumption that a complete washout occurred and there is no endogenous source of the analyte.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
NA NA NA NA NA FALSE
NA NA NA NA NA TRUE
NA NA NA NA both FALSE
NA NA NA NA both TRUE
NA NA NA NA conc FALSE
NA NA NA NA conc TRUE
NA NA NA NA dose FALSE
NA NA NA NA dose TRUE
NA NA both TRUE NA TRUE
NA NA both TRUE both TRUE
NA NA both TRUE conc TRUE
NA NA both TRUE dose TRUE
NA NA dose FALSE NA FALSE
NA NA dose FALSE NA TRUE
NA NA dose FALSE both FALSE
NA NA dose FALSE both TRUE
NA NA dose FALSE conc FALSE
NA NA dose FALSE conc TRUE
NA NA dose FALSE dose FALSE
NA NA dose FALSE dose TRUE
NA NA dose TRUE NA FALSE
NA NA dose TRUE NA TRUE
NA NA dose TRUE both FALSE
NA NA dose TRUE both TRUE
NA NA dose TRUE conc FALSE
NA NA dose TRUE conc TRUE
NA NA dose TRUE dose FALSE
NA NA dose TRUE dose TRUE

After an IV bolus without a concentration next

Between an IV bolus and anything other than a concentration, interpolation cannot occur. Return NA

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
both TRUE NA NA NA FALSE
both TRUE NA NA NA TRUE
both TRUE NA NA both FALSE
both TRUE NA NA both TRUE
both TRUE NA NA dose FALSE
both TRUE NA NA dose TRUE
dose TRUE NA NA NA FALSE
dose TRUE NA NA NA TRUE
dose TRUE NA NA both FALSE
dose TRUE NA NA both TRUE
dose TRUE NA NA dose FALSE
dose TRUE NA NA dose TRUE

Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose

Extrapolate when the previous measurement is a concentration, and the current event is a dose or nothing. If the previous concentration measurement is below the limit of quantification (zero), then return zero.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
conc NA NA NA dose FALSE
conc NA NA NA dose TRUE
conc NA dose FALSE both FALSE
conc NA dose FALSE both TRUE
conc NA dose FALSE conc FALSE
conc NA dose FALSE conc TRUE
conc NA dose FALSE dose FALSE
conc NA dose FALSE dose TRUE
conc NA dose TRUE both FALSE
conc NA dose TRUE conc FALSE
conc NA dose TRUE dose FALSE

Immediately after an IV bolus with a concentration next

Calculate C0 for the time immediately after an IV bolus. First, attempt using log slope back-extrapolation. If that fails, use the first concentration after the dose as C0.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
both FALSE both TRUE conc TRUE
both FALSE dose TRUE conc TRUE
both TRUE both TRUE conc TRUE
both TRUE dose TRUE conc TRUE
conc NA both TRUE conc TRUE
conc NA dose TRUE conc TRUE
dose FALSE both TRUE conc TRUE
dose FALSE dose TRUE conc TRUE
dose TRUE both TRUE conc TRUE
dose TRUE dose TRUE conc TRUE

Interpolation

With concentrations before and after and not an IV bolus before, interpolate between observed concentrations.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
both FALSE NA NA both FALSE
both FALSE NA NA both TRUE
both FALSE NA NA conc FALSE
both FALSE NA NA conc TRUE
conc NA NA NA both FALSE
conc NA NA NA both TRUE
conc NA NA NA conc FALSE
conc NA NA NA conc TRUE

After all events, concentration before

Extrapolate from the concentration data after the last dose.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
conc NA NA NA NA FALSE
conc NA NA NA NA TRUE
conc NA dose FALSE NA FALSE
conc NA dose FALSE NA TRUE
conc NA dose TRUE NA FALSE

After an IV bolus with a concentration next

First, calculate C0 using log slope back-extrapolation (falling back to the first post-dose concentration if that fails). Then, interpolate between C0 and the first post-dose concentration.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
both TRUE NA NA conc FALSE
both TRUE NA NA conc TRUE
dose TRUE NA NA conc FALSE
dose TRUE NA NA conc TRUE

After a dose with no event and a concentration after

If there is a non-IV bolus dose before, nothing at the current time, and a concentration after, extrapolate from prior data to the concentration at the time of dosing then interpolate between the dosing time and the requested output time.

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After
dose FALSE NA NA conc FALSE
dose FALSE NA NA conc TRUE

Appendix: Complete Methods Table

Event Before IV Bolus Before Event At IV Bolus At Event After Instant After Method Used
NA NA NA NA NA FALSE Before all events
NA NA NA NA NA TRUE Before all events
NA NA NA NA both FALSE Before all events
NA NA NA NA both TRUE Before all events
NA NA NA NA conc FALSE Before all events
NA NA NA NA conc TRUE Before all events
NA NA NA NA dose FALSE Before all events
NA NA NA NA dose TRUE Before all events
NA NA both FALSE NA FALSE Copy
NA NA both FALSE NA TRUE Copy
NA NA both FALSE both FALSE Copy
NA NA both FALSE both TRUE Copy
NA NA both FALSE conc FALSE Copy
NA NA both FALSE conc TRUE Copy
NA NA both FALSE dose FALSE Copy
NA NA both FALSE dose TRUE Copy
NA NA both TRUE NA FALSE Copy
NA NA both TRUE NA TRUE Before all events
NA NA both TRUE both FALSE Copy
NA NA both TRUE both TRUE Before all events
NA NA both TRUE conc FALSE Copy
NA NA both TRUE conc TRUE Before all events
NA NA both TRUE dose FALSE Copy
NA NA both TRUE dose TRUE Before all events
NA NA conc NA NA FALSE Copy
NA NA conc NA NA TRUE Copy
NA NA conc NA both FALSE Copy
NA NA conc NA both TRUE Copy
NA NA conc NA conc FALSE Copy
NA NA conc NA conc TRUE Copy
NA NA conc NA dose FALSE Copy
NA NA conc NA dose TRUE Copy
NA NA dose FALSE NA FALSE Before all events
NA NA dose FALSE NA TRUE Before all events
NA NA dose FALSE both FALSE Before all events
NA NA dose FALSE both TRUE Before all events
NA NA dose FALSE conc FALSE Before all events
NA NA dose FALSE conc TRUE Before all events
NA NA dose FALSE dose FALSE Before all events
NA NA dose FALSE dose TRUE Before all events
NA NA dose TRUE NA FALSE Before all events
NA NA dose TRUE NA TRUE Before all events
NA NA dose TRUE both FALSE Before all events
NA NA dose TRUE both TRUE Before all events
NA NA dose TRUE conc FALSE Before all events
NA NA dose TRUE conc TRUE Before all events
NA NA dose TRUE dose FALSE Before all events
NA NA dose TRUE dose TRUE Before all events
both FALSE NA NA NA FALSE Doses with no concentrations between
both FALSE NA NA NA TRUE Doses with no concentrations between
both FALSE NA NA both FALSE Interpolation
both FALSE NA NA both TRUE Interpolation
both FALSE NA NA conc FALSE Interpolation
both FALSE NA NA conc TRUE Interpolation
both FALSE NA NA dose FALSE Doses with no concentrations between
both FALSE NA NA dose TRUE Doses with no concentrations between
both FALSE both FALSE NA FALSE Copy
both FALSE both FALSE NA TRUE Copy
both FALSE both FALSE both FALSE Copy
both FALSE both FALSE both TRUE Copy
both FALSE both FALSE conc FALSE Copy
both FALSE both FALSE conc TRUE Copy
both FALSE both FALSE dose FALSE Copy
both FALSE both FALSE dose TRUE Copy
both FALSE both TRUE NA FALSE Copy
both FALSE both TRUE NA TRUE Immediately after an IV bolus without a concentration next
both FALSE both TRUE both FALSE Copy
both FALSE both TRUE both TRUE Immediately after an IV bolus without a concentration next
both FALSE both TRUE conc FALSE Copy
both FALSE both TRUE conc TRUE Immediately after an IV bolus with a concentration next
both FALSE both TRUE dose FALSE Copy
both FALSE both TRUE dose TRUE Immediately after an IV bolus without a concentration next
both FALSE conc NA NA FALSE Copy
both FALSE conc NA NA TRUE Copy
both FALSE conc NA both FALSE Copy
both FALSE conc NA both TRUE Copy
both FALSE conc NA conc FALSE Copy
both FALSE conc NA conc TRUE Copy
both FALSE conc NA dose FALSE Copy
both FALSE conc NA dose TRUE Copy
both FALSE dose FALSE NA FALSE Doses with no concentrations between
both FALSE dose FALSE NA TRUE Doses with no concentrations between
both FALSE dose FALSE both FALSE Doses with no concentrations between
both FALSE dose FALSE both TRUE Doses with no concentrations between
both FALSE dose FALSE conc FALSE Doses with no concentrations between
both FALSE dose FALSE conc TRUE Doses with no concentrations between
both FALSE dose FALSE dose FALSE Doses with no concentrations between
both FALSE dose FALSE dose TRUE Doses with no concentrations between
both FALSE dose TRUE NA FALSE Doses with no concentrations between
both FALSE dose TRUE NA TRUE Immediately after an IV bolus without a concentration next
both FALSE dose TRUE both FALSE Doses with no concentrations between
both FALSE dose TRUE both TRUE Immediately after an IV bolus without a concentration next
both FALSE dose TRUE conc FALSE Doses with no concentrations between
both FALSE dose TRUE conc TRUE Immediately after an IV bolus with a concentration next
both FALSE dose TRUE dose FALSE Doses with no concentrations between
both FALSE dose TRUE dose TRUE Immediately after an IV bolus without a concentration next
both TRUE NA NA NA FALSE After an IV bolus without a concentration next
both TRUE NA NA NA TRUE After an IV bolus without a concentration next
both TRUE NA NA both FALSE After an IV bolus without a concentration next
both TRUE NA NA both TRUE After an IV bolus without a concentration next
both TRUE NA NA conc FALSE After an IV bolus with a concentration next
both TRUE NA NA conc TRUE After an IV bolus with a concentration next
both TRUE NA NA dose FALSE After an IV bolus without a concentration next
both TRUE NA NA dose TRUE After an IV bolus without a concentration next
both TRUE both FALSE NA FALSE Copy
both TRUE both FALSE NA TRUE Copy
both TRUE both FALSE both FALSE Copy
both TRUE both FALSE both TRUE Copy
both TRUE both FALSE conc FALSE Copy
both TRUE both FALSE conc TRUE Copy
both TRUE both FALSE dose FALSE Copy
both TRUE both FALSE dose TRUE Copy
both TRUE both TRUE NA FALSE Copy
both TRUE both TRUE NA TRUE Immediately after an IV bolus without a concentration next
both TRUE both TRUE both FALSE Copy
both TRUE both TRUE both TRUE Immediately after an IV bolus without a concentration next
both TRUE both TRUE conc FALSE Copy
both TRUE both TRUE conc TRUE Immediately after an IV bolus with a concentration next
both TRUE both TRUE dose FALSE Copy
both TRUE both TRUE dose TRUE Immediately after an IV bolus without a concentration next
both TRUE conc NA NA FALSE Copy
both TRUE conc NA NA TRUE Copy
both TRUE conc NA both FALSE Copy
both TRUE conc NA both TRUE Copy
both TRUE conc NA conc FALSE Copy
both TRUE conc NA conc TRUE Copy
both TRUE conc NA dose FALSE Copy
both TRUE conc NA dose TRUE Copy
both TRUE dose FALSE NA FALSE Doses with no concentrations between
both TRUE dose FALSE NA TRUE Doses with no concentrations between
both TRUE dose FALSE both FALSE Doses with no concentrations between
both TRUE dose FALSE both TRUE Doses with no concentrations between
both TRUE dose FALSE conc FALSE Doses with no concentrations between
both TRUE dose FALSE conc TRUE Doses with no concentrations between
both TRUE dose FALSE dose FALSE Doses with no concentrations between
both TRUE dose FALSE dose TRUE Doses with no concentrations between
both TRUE dose TRUE NA FALSE Doses with no concentrations between
both TRUE dose TRUE NA TRUE Immediately after an IV bolus without a concentration next
both TRUE dose TRUE both FALSE Doses with no concentrations between
both TRUE dose TRUE both TRUE Immediately after an IV bolus without a concentration next
both TRUE dose TRUE conc FALSE Doses with no concentrations between
both TRUE dose TRUE conc TRUE Immediately after an IV bolus with a concentration next
both TRUE dose TRUE dose FALSE Doses with no concentrations between
both TRUE dose TRUE dose TRUE Immediately after an IV bolus without a concentration next
conc NA NA NA NA FALSE After all events, concentration before
conc NA NA NA NA TRUE After all events, concentration before
conc NA NA NA both FALSE Interpolation
conc NA NA NA both TRUE Interpolation
conc NA NA NA conc FALSE Interpolation
conc NA NA NA conc TRUE Interpolation
conc NA NA NA dose FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA NA NA dose TRUE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA both FALSE NA FALSE Copy
conc NA both FALSE NA TRUE Copy
conc NA both FALSE both FALSE Copy
conc NA both FALSE both TRUE Copy
conc NA both FALSE conc FALSE Copy
conc NA both FALSE conc TRUE Copy
conc NA both FALSE dose FALSE Copy
conc NA both FALSE dose TRUE Copy
conc NA both TRUE NA FALSE Copy
conc NA both TRUE NA TRUE Immediately after an IV bolus without a concentration next
conc NA both TRUE both FALSE Copy
conc NA both TRUE both TRUE Immediately after an IV bolus without a concentration next
conc NA both TRUE conc FALSE Copy
conc NA both TRUE conc TRUE Immediately after an IV bolus with a concentration next
conc NA both TRUE dose FALSE Copy
conc NA both TRUE dose TRUE Immediately after an IV bolus without a concentration next
conc NA conc NA NA FALSE Copy
conc NA conc NA NA TRUE Copy
conc NA conc NA both FALSE Copy
conc NA conc NA both TRUE Copy
conc NA conc NA conc FALSE Copy
conc NA conc NA conc TRUE Copy
conc NA conc NA dose FALSE Copy
conc NA conc NA dose TRUE Copy
conc NA dose FALSE NA FALSE After all events, concentration before
conc NA dose FALSE NA TRUE After all events, concentration before
conc NA dose FALSE both FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose FALSE both TRUE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose FALSE conc FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose FALSE conc TRUE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose FALSE dose FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose FALSE dose TRUE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose TRUE NA FALSE After all events, concentration before
conc NA dose TRUE NA TRUE Immediately after an IV bolus without a concentration next
conc NA dose TRUE both FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose TRUE both TRUE Immediately after an IV bolus without a concentration next
conc NA dose TRUE conc FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose TRUE conc TRUE Immediately after an IV bolus with a concentration next
conc NA dose TRUE dose FALSE Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose
conc NA dose TRUE dose TRUE Immediately after an IV bolus without a concentration next
dose FALSE NA NA NA FALSE Doses with no concentrations between
dose FALSE NA NA NA TRUE Doses with no concentrations between
dose FALSE NA NA both FALSE Doses with no concentrations between
dose FALSE NA NA both TRUE Doses with no concentrations between
dose FALSE NA NA conc FALSE After a dose with no event and a concentration after
dose FALSE NA NA conc TRUE After a dose with no event and a concentration after
dose FALSE NA NA dose FALSE Doses with no concentrations between
dose FALSE NA NA dose TRUE Doses with no concentrations between
dose FALSE both FALSE NA FALSE Copy
dose FALSE both FALSE NA TRUE Copy
dose FALSE both FALSE both FALSE Copy
dose FALSE both FALSE both TRUE Copy
dose FALSE both FALSE conc FALSE Copy
dose FALSE both FALSE conc TRUE Copy
dose FALSE both FALSE dose FALSE Copy
dose FALSE both FALSE dose TRUE Copy
dose FALSE both TRUE NA FALSE Copy
dose FALSE both TRUE NA TRUE Immediately after an IV bolus without a concentration next
dose FALSE both TRUE both FALSE Copy
dose FALSE both TRUE both TRUE Immediately after an IV bolus without a concentration next
dose FALSE both TRUE conc FALSE Copy
dose FALSE both TRUE conc TRUE Immediately after an IV bolus with a concentration next
dose FALSE both TRUE dose FALSE Copy
dose FALSE both TRUE dose TRUE Immediately after an IV bolus without a concentration next
dose FALSE conc NA NA FALSE Copy
dose FALSE conc NA NA TRUE Copy
dose FALSE conc NA both FALSE Copy
dose FALSE conc NA both TRUE Copy
dose FALSE conc NA conc FALSE Copy
dose FALSE conc NA conc TRUE Copy
dose FALSE conc NA dose FALSE Copy
dose FALSE conc NA dose TRUE Copy
dose FALSE dose FALSE NA FALSE Doses with no concentrations between
dose FALSE dose FALSE NA TRUE Doses with no concentrations between
dose FALSE dose FALSE both FALSE Doses with no concentrations between
dose FALSE dose FALSE both TRUE Doses with no concentrations between
dose FALSE dose FALSE conc FALSE Doses with no concentrations between
dose FALSE dose FALSE conc TRUE Doses with no concentrations between
dose FALSE dose FALSE dose FALSE Doses with no concentrations between
dose FALSE dose FALSE dose TRUE Doses with no concentrations between
dose FALSE dose TRUE NA FALSE Doses with no concentrations between
dose FALSE dose TRUE NA TRUE Immediately after an IV bolus without a concentration next
dose FALSE dose TRUE both FALSE Doses with no concentrations between
dose FALSE dose TRUE both TRUE Immediately after an IV bolus without a concentration next
dose FALSE dose TRUE conc FALSE Doses with no concentrations between
dose FALSE dose TRUE conc TRUE Immediately after an IV bolus with a concentration next
dose FALSE dose TRUE dose FALSE Doses with no concentrations between
dose FALSE dose TRUE dose TRUE Immediately after an IV bolus without a concentration next
dose TRUE NA NA NA FALSE After an IV bolus without a concentration next
dose TRUE NA NA NA TRUE After an IV bolus without a concentration next
dose TRUE NA NA both FALSE After an IV bolus without a concentration next
dose TRUE NA NA both TRUE After an IV bolus without a concentration next
dose TRUE NA NA conc FALSE After an IV bolus with a concentration next
dose TRUE NA NA conc TRUE After an IV bolus with a concentration next
dose TRUE NA NA dose FALSE After an IV bolus without a concentration next
dose TRUE NA NA dose TRUE After an IV bolus without a concentration next
dose TRUE both FALSE NA FALSE Copy
dose TRUE both FALSE NA TRUE Copy
dose TRUE both FALSE both FALSE Copy
dose TRUE both FALSE both TRUE Copy
dose TRUE both FALSE conc FALSE Copy
dose TRUE both FALSE conc TRUE Copy
dose TRUE both FALSE dose FALSE Copy
dose TRUE both FALSE dose TRUE Copy
dose TRUE both TRUE NA FALSE Copy
dose TRUE both TRUE NA TRUE Immediately after an IV bolus without a concentration next
dose TRUE both TRUE both FALSE Copy
dose TRUE both TRUE both TRUE Immediately after an IV bolus without a concentration next
dose TRUE both TRUE conc FALSE Copy
dose TRUE both TRUE conc TRUE Immediately after an IV bolus with a concentration next
dose TRUE both TRUE dose FALSE Copy
dose TRUE both TRUE dose TRUE Immediately after an IV bolus without a concentration next
dose TRUE conc NA NA FALSE Copy
dose TRUE conc NA NA TRUE Copy
dose TRUE conc NA both FALSE Copy
dose TRUE conc NA both TRUE Copy
dose TRUE conc NA conc FALSE Copy
dose TRUE conc NA conc TRUE Copy
dose TRUE conc NA dose FALSE Copy
dose TRUE conc NA dose TRUE Copy
dose TRUE dose FALSE NA FALSE Doses with no concentrations between
dose TRUE dose FALSE NA TRUE Doses with no concentrations between
dose TRUE dose FALSE both FALSE Doses with no concentrations between
dose TRUE dose FALSE both TRUE Doses with no concentrations between
dose TRUE dose FALSE conc FALSE Doses with no concentrations between
dose TRUE dose FALSE conc TRUE Doses with no concentrations between
dose TRUE dose FALSE dose FALSE Doses with no concentrations between
dose TRUE dose FALSE dose TRUE Doses with no concentrations between
dose TRUE dose TRUE NA FALSE Doses with no concentrations between
dose TRUE dose TRUE NA TRUE Immediately after an IV bolus without a concentration next
dose TRUE dose TRUE both FALSE Doses with no concentrations between
dose TRUE dose TRUE both TRUE Immediately after an IV bolus without a concentration next
dose TRUE dose TRUE conc FALSE Doses with no concentrations between
dose TRUE dose TRUE conc TRUE Immediately after an IV bolus with a concentration next
dose TRUE dose TRUE dose FALSE Doses with no concentrations between
dose TRUE dose TRUE dose TRUE Immediately after an IV bolus without a concentration next