Bisulfite-treated RNA non-conversion in a set of samples is analysed as follows: each sample's Poisson parameter is estimated, and non-conversion p-values are calculated for each sample and adjusted for multiple testing. Finally, combined non-conversion p-value and standard error of the non-conversion are calculated on the intersection of the set of samples. A low combined non-conversion p-value points to methylation of the corresponding RNA cytosine, or another event blocking bisulfite conversion.
| Version: | 0.2.1 |
| Depends: | R (≥ 3.3.2) |
| Imports: | MASS, knitr, graphics, stats, utils |
| Suggests: | IHW, testthat |
| Published: | 2017-04-12 |
| Author: | Carine Legrand |
| Maintainer: | Carine Legrand <c.legrand at dkfz.de> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| Citation: | BisRNA citation info |
| CRAN checks: | BisRNA results |
| Reference manual: | BisRNA.pdf |
| Package source: | BisRNA_0.2.1.tar.gz |
| Windows binaries: | r-devel: BisRNA_0.2.1.zip, r-release: BisRNA_0.2.1.zip, r-oldrel: BisRNA_0.2.1.zip |
| OS X El Capitan binaries: | r-release: BisRNA_0.2.1.tgz |
| OS X Mavericks binaries: | r-oldrel: BisRNA_0.2.1.tgz |
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