Bios2cor: From Biological Sequences and Simulations to Correlation Analysis

Utilities for computation and analysis of correlation/co-variation in multiple sequence alignments and in side chain motions during molecular dynamics simulations. Features include the computation of correlation/co-variation scores using a variety of scoring functions between either sequence positions in alignments or side chain dihedral angles in molecular dynamics simulations and to analyze the correlation/co-variation matrix through a variety of tools including network representation and principal components analysis. In addition, several utility functions are based on the R graphical environment to provide friendly tools for help in data interpretation. Examples of sequence co-variation analysis and utility tools are provided in: Pele J, Moreau M, Abdi H, Rodien P, Castel H, Chabbert M. (2014) <doi:10.1002/prot.24570>. This work was supported by the French National Research Agency (Grant number: ANR-11-BSV2-026).

Version: 1.2
Depends: R (≥ 3.1), bio3d, circular, bigmemory, parallel
Imports: igraph
Published: 2017-09-07
Author: Bruck Taddese [aut], Antoine Garnier [aut], Madeline Deniaud [aut], Julien Pele [ctb], Lea Bellenger [ctb], Jean-Michel Becu [ctb], Marie Chabbert [cre]
Maintainer: Marie Chabbert <marie.chabbert at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: Bios2cor results


Reference manual: Bios2cor.pdf
Package source: Bios2cor_1.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: Bios2cor_1.2.tgz
OS X Mavericks binaries: r-oldrel: Bios2cor_1.2.tgz
Old sources: Bios2cor archive


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