mrgsolve: Simulate from ODE-Based Population PK/PD and Systems Pharmacology Models

Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' (<>).

Version: 0.8.10
Depends: R (≥ 3.1.2), methods
Imports: Rcpp (≥ 0.12.12), dplyr (≥ 0.7.4), magrittr (≥ 1.5), lazyeval (≥ 0.1.10), RcppArmadillo (≥ 0.7.900.2.0), tibble (≥ 1.2)
LinkingTo: Rcpp (≥ 0.12.12), RcppArmadillo (≥ 0.7.900.2.0), BH (≥ 1.62.0-1)
Suggests: lattice, testthat, XML, rmarkdown
Published: 2017-11-01
Author: Kyle T Baron [aut, cre], Alan C Hindmarsh [ctb], Linda R Petzold [ctb], Bill Gillespie [ctb], Charles Margossian [ctb], Devin Pastoor [ctb], Metrum Research Group LLC [cph]
Maintainer: Kyle T Baron <kyleb at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright: Metrum Research Group, LLC 2017
NeedsCompilation: yes
In views: Pharmacokinetics
CRAN checks: mrgsolve results


Reference manual: mrgsolve.pdf
Package source: mrgsolve_0.8.10.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: mrgsolve_0.8.10.tgz
OS X Mavericks binaries: r-oldrel: mrgsolve_0.8.10.tgz
Old sources: mrgsolve archive


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