Functions for fitting linear and non-linear mixed-effects models using stochastic differential equations (SDEs). The provided pipeline relies on the coupling of the FOCE algorithm and Kalman filtering as outlined by Klim et al (2009) <doi:10.1016/j.cmpb.2009.02.001> and has been validated against the proprietary software NONMEM (Tornøe et al, 2005, <doi:10.1007/s11095-005-5269-5>). Further functions are provided for finding smoothed estimates of model states and for simulation. The package allows for any multivariate non-linear time-variant model to be specified, and it also handles multidimensional input, covariates, missing observations, and specification of dosage regimen.
| Version: | 0.8-11 |
| Imports: | deSolve, graphics, MASS, numDeriv, stats, ucminf |
| Suggests: | datasets |
| Published: | 2017-11-03 |
| Author: | Stig Bousgaard Mortensen, Søren Klim |
| Maintainer: | Robert Miller <robert.miller at tu-dresden.de> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: | http://www.imm.dtu.dk/psm |
| NeedsCompilation: | yes |
| CRAN checks: | PSM results |
| Reference manual: | PSM.pdf |
| Vignettes: |
Population Stochastic Modelling: Model definition, description and examples |
| Package source: | PSM_0.8-11.tar.gz |
| Windows binaries: | r-devel: PSM_0.8-11.zip, r-release: PSM_0.8-11.zip, r-oldrel: PSM_0.8-11.zip |
| OS X binaries: | r-release: PSM_0.8-11.tgz, r-oldrel: PSM_0.8-11.tgz |
| Old sources: | PSM archive |
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