This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.
| Version: | 0.4.0 |
| Depends: | R (≥ 3.0.0), numDeriv |
| Published: | 2018-04-02 |
| Author: | Kyun-Seop Bae [aut] |
| Maintainer: | Kyun-Seop Bae <k at acr.kr> |
| License: | GPL-3 |
| Copyright: | 2017-, Kyun-Seop Bae |
| URL: | https://cran.r-project.org/package=wnl |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | wnl results |
| Reference manual: | wnl.pdf |
| Package source: | wnl_0.4.0.tar.gz |
| Windows binaries: | r-devel: wnl_0.4.0.zip, r-release: wnl_0.4.0.zip, r-oldrel: wnl_0.4.0.zip |
| OS X binaries: | r-release: wnl_0.4.0.tgz, r-oldrel: wnl_0.4.0.tgz |
| Old sources: | wnl archive |
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