Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).
| Version: | 0.8.12 |
| Depends: | R (≥ 3.1.2), methods |
| Imports: | Rcpp (≥ 0.12.12), dplyr (≥ 0.7.4), magrittr (≥ 1.5), RcppArmadillo (≥ 0.7.900.2.0), tibble (≥ 1.2), rlang (≥ 0.2.0) |
| LinkingTo: | Rcpp (≥ 0.12.12), RcppArmadillo (≥ 0.7.900.2.0), BH (≥ 1.62.0-1) |
| Suggests: | lattice, testthat, xml2 (≥ 1.2.0), rmarkdown |
| Published: | 2018-04-27 |
| Author: | Kyle T Baron [aut, cre], Alan C Hindmarsh [ctb], Linda R Petzold [ctb], Bill Gillespie [ctb], Charles Margossian [ctb], Devin Pastoor [ctb], Metrum Research Group LLC [cph] |
| Maintainer: | Kyle T Baron <kyleb at metrumrg.com> |
| BugReports: | https://github.com/metrumresearchgroup/mrgsolve/issues |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| Copyright: | Metrum Research Group, LLC 2018 |
| URL: | https://github.com/metrumresearchgroup/mrgsolve |
| NeedsCompilation: | yes |
| In views: | Pharmacokinetics |
| CRAN checks: | mrgsolve results |
| Reference manual: | mrgsolve.pdf |
| Package source: | mrgsolve_0.8.12.tar.gz |
| Windows binaries: | r-devel: mrgsolve_0.8.12.zip, r-release: mrgsolve_0.8.12.zip, r-oldrel: mrgsolve_0.8.12.zip |
| OS X binaries: | r-release: mrgsolve_0.8.12.tgz, r-oldrel: mrgsolve_0.8.12.tgz |
| Old sources: | mrgsolve archive |
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