FamSKAT-RC is a family-based association kernel test for both rare and common variants. This test is general and several special cases are known as other methods: famSKAT, which only focuses on rare variants in family-based data, SKAT, which focuses on rare variants in population-based data (unrelated individuals), and SKAT-RC, which focuses on both rare and common variants in population-based data. When one applies famSKAT-RC and sets the value of phi to 1, famSKAT-RC becomes famSKAT. When one applies famSKAT-RC and set the value of phi to 1 and the kinship matrix to the identity matrix, famSKAT-RC becomes SKAT. When one applies famSKAT-RC and set the kinship matrix (fullkins) to the identity matrix (and phi is not equal to 1), famSKAT-RC becomes SKAT-RC. We also include a small sample synthetic pedigree to demonstrate the method with. For more details see Saad M and Wijsman EM (2014) <doi:10.1002/gepi.21844>.
| Version: | 1.1.0 |
| Depends: | R (≥ 3.4.1) |
| Imports: | CompQuadForm, kinship2, coxme, bdsmatrix |
| Published: | 2017-11-09 |
| Author: | Khalid B. Kunji [aut, cre], Mohamad Saad [aut] |
| Maintainer: | Khalid B. Kunji <kkunji at hbku.edu.qa> |
| License: | GPL (≥ 3) |
| URL: | https://www.r-project.org, https://www.ncbi.nlm.nih.gov/pubmed/25132070 |
| NeedsCompilation: | no |
| CRAN checks: | famSKATRC results |
| Reference manual: | famSKATRC.pdf |
| Package source: | famSKATRC_1.1.0.tar.gz |
| Windows binaries: | r-devel: famSKATRC_1.1.0.zip, r-release: famSKATRC_1.1.0.zip, r-oldrel: famSKATRC_1.1.0.zip |
| OS X binaries: | r-release: famSKATRC_1.1.0.tgz, r-oldrel: famSKATRC_1.1.0.tgz |
| Old sources: | famSKATRC archive |
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