iva: Instrumental Variable Analysis in Case-Control Association Studies

Mendelian randomization (MR) analysis is a special case of instrumental variable analysis with genetic instruments. It is used to estimate the unconfounded causal effect of an exposure. This package implements estimating and testing methods in Zhang et al. (2019) for MR analysis in case-control studies. It (1) estimates the causal effect of a quantitative exposure by the quasi empirical likelihood approach; (2) uses Lagrange multiplier test for testing the presence of causal; (3) provides a test for the presence of confounder.

Version: 0.1.0
Imports: ucminf, Formula
Published: 2019-01-19
Author: Han Zhang, Kai Yu
Maintainer: Han Zhang <han.zhang2 at nih.gov>
License: MIT + file LICENSE
NeedsCompilation: no
CRAN checks: iva results


Reference manual: iva.pdf
Package source: iva_0.1.0.tar.gz
Windows binaries: r-devel: iva_0.1.0.zip, r-release: iva_0.1.0.zip, r-oldrel: iva_0.1.0.zip
OS X binaries: r-release: iva_0.1.0.tgz, r-oldrel: iva_0.1.0.tgz


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