dtpcrm: Dose Transition Pathways for Continual Reassessment Method

Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.

Version: 0.1.0
Imports: diagram, dfcrm
Suggests: knitr, rmarkdown, testthat
Published: 2019-04-10
Author: Christina Yap [aut, cre], Daniel Slade [aut], Kristian Brock [aut], Yi Pan [aut]
Maintainer: Christina Yap <yapchristina17 at gmail.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: dtpcrm results


Reference manual: dtpcrm.pdf
Vignettes: dtpcrm: Dose Transition Pathways with Continual Reassessment Method
Package source: dtpcrm_0.1.0.tar.gz
Windows binaries: r-devel: dtpcrm_0.1.0.zip, r-release: dtpcrm_0.1.0.zip, r-oldrel: dtpcrm_0.1.0.zip
OS X binaries: r-release: dtpcrm_0.1.0.tgz, r-oldrel: not available


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