nlmixr: Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 1.0.0-7
Depends: R (≥ 3.2)
Imports: Rcpp (≥ 0.12.3), brew, lattice, parallel, lbfgs, dparser, methods, ggplot2, memoise, rex, minqa, Matrix, numDeriv, R.utils, n1qn1, PreciseSums, fastGHQuad, crayon, cli, RcppArmadillo (≥ 0.5.600.2.0), vpc (≥ 1.0.0), RxODE (≥ 0.8.0-4), nlme, magrittr, tidyr
LinkingTo: dparser (≥ 0.1.8), Rcpp (≥ 0.12.3), RcppEigen (≥, StanHeaders, BH
Suggests: knitr, rmarkdown, dplyr, data.table, lbfgsb3, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf
Published: 2018-09-23
Author: Matthew Fidler [aut], Yuan Xiong [aut], Rik Schoemaker [aut], Justin Wilkins [aut], Mirjam Trame [aut], Teun Post [aut], Robert Leary [ctb], Wenping Wang [aut, cre], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], David Ardia [cph], Katharine Mullen [cph]
Maintainer: Wenping Wang <wwang8198 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
In views: Pharmacokinetics
CRAN checks: nlmixr results


Reference manual: nlmixr.pdf
Vignettes: Installing nlmixr
Running PK models with nlmixr
Package source: nlmixr_1.0.0-7.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X binaries: r-release: nlmixr_1.1.0-9.tgz, r-oldrel: nlmixr_1.1.0-9.tgz
Old sources: nlmixr archive


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