Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: | 1.0.0-7 |
| Depends: | R (≥ 3.2) |
| Imports: | Rcpp (≥ 0.12.3), brew, lattice, parallel, lbfgs, dparser, methods, ggplot2, memoise, rex, minqa, Matrix, numDeriv, R.utils, n1qn1, PreciseSums, fastGHQuad, crayon, cli, RcppArmadillo (≥ 0.5.600.2.0), vpc (≥ 1.0.0), RxODE (≥ 0.8.0-4), nlme, magrittr, tidyr |
| LinkingTo: | dparser (≥ 0.1.8), Rcpp (≥ 0.12.3), RcppEigen (≥ 0.3.3.3.0), StanHeaders, BH |
| Suggests: | knitr, rmarkdown, dplyr, data.table, lbfgsb3, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf |
| Published: | 2018-09-23 |
| Author: | Matthew Fidler [aut], Yuan Xiong [aut], Rik Schoemaker [aut], Justin Wilkins [aut], Mirjam Trame [aut], Teun Post [aut], Robert Leary [ctb], Wenping Wang [aut, cre], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], David Ardia [cph], Katharine Mullen [cph] |
| Maintainer: | Wenping Wang <wwang8198 at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: | https://github.com/nlmixrdevelopment/nlmixr |
| NeedsCompilation: | yes |
| In views: | Pharmacokinetics |
| CRAN checks: | nlmixr results |
| Reference manual: | nlmixr.pdf |
| Vignettes: |
Installing nlmixr Running PK models with nlmixr |
| Package source: | nlmixr_1.0.0-7.tar.gz |
| Windows binaries: | r-devel: nlmixr_1.0.0-7.zip, r-release: nlmixr_1.0.0-7.zip, r-oldrel: nlmixr_1.0.0-7.zip |
| OS X binaries: | r-release: nlmixr_1.1.0-9.tgz, r-oldrel: nlmixr_1.1.0-9.tgz |
| Old sources: | nlmixr archive |
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