adoptr: Adaptive Optimal Two-Stage Designs in R

Optimize one or two-arm, two-stage designs for clinical trials with respect to several pre-implemented objective criteria or implement custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs. Statistics in Medicine. 2019;1–13. <doi:10.1002/sim.8291> for details.

Version: 0.2.2
Imports: nloptr, methods
Suggests: knitr, rmarkdown, testthat, covr, rpact, vdiffr
Published: 2019-07-02
Author: Kevin Kunzmann [aut, cre], Maximilian Pilz [aut]
Maintainer: Kevin Kunzmann <kevin.kunzmann at>
License: MIT + file LICENSE
NeedsCompilation: no
Materials: README NEWS
CRAN checks: adoptr results


Reference manual: adoptr.pdf
Vignettes: quickstart
Composite Scores
Conditional Scores and Constraints
Defining New Scores
Working with priors
Package source: adoptr_0.2.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X binaries: r-release: adoptr_0.2.0.tgz, r-oldrel: adoptr_0.2.0.tgz
Old sources: adoptr archive


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