pksensi: Global Sensitivity Analysis in Physiologically Based Kinetic Modeling

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in pharmacokinetic (PK) models, especially the physiologically-based pharmacokinetic (PBPK) model with multivariate outputs. The package also provide some functions to check the sensitivity measures and its convergence of model parameters.

Version: 1.1.2
Depends: R (≥ 3.5)
Imports: ggplot2, data.table, deSolve, dplyr, getPass, magrittr, reshape
Suggests: knitr, rmarkdown, testthat, viridis
Published: 2019-06-30
Author: Nan-Hung Hsieh ORCID iD [aut, cre], Brad Reisfeld [aut], Weihsueh A. Chiu ORCID iD [aut]
Maintainer: Nan-Hung Hsieh <nhsieh at>
License: GPL-3 | file LICENSE
NeedsCompilation: no
Materials: NEWS
CRAN checks: pksensi results


Reference manual: pksensi.pdf
Vignettes: Acetaminophen-PBPK model
One-compartment PK model
Package source: pksensi_1.1.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X binaries: r-release: pksensi_1.1.2.tgz, r-oldrel: pksensi_1.1.2.tgz
Old sources: pksensi archive


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