Performs comparative bioavailability-calculations for the EMA's Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' and 'Method B', detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to preserve the consumer risk. Average Bioequivalence (ABE) - optionally with tighter (EMA: NTIDs) or wider limits (GCC: Cmax) - is implemented as well.
Version: | 1.0.8 |
Imports: | readxl (≥ 1.0.0), PowerTOST (≥ 1.3.3), lmerTest, nlme, graphics, grDevices |
Suggests: | knitr, rmarkdown, testthat, devtools |
Published: | 2019-06-14 |
Author: | Helmut Schütz |
Maintainer: | Helmut Schütz <helmut.schuetz at bebac.at> |
BugReports: | https://github.com/Helmut01/replicateBE/issues |
License: | GPL (≥ 3) |
URL: | https://github.com/Helmut01/replicateBE |
NeedsCompilation: | no |
Materials: | NEWS |
CRAN checks: | replicateBE results |
Reference manual: | replicateBE.pdf |
Vignettes: |
replicateBE |
Package source: | replicateBE_1.0.8.tar.gz |
Windows binaries: | r-devel: replicateBE_1.0.8.zip, r-release: replicateBE_1.0.8.zip, r-oldrel: replicateBE_1.0.8.zip |
OS X binaries: | r-release: replicateBE_1.0.8.tgz, r-oldrel: replicateBE_1.0.8.tgz |
Old sources: | replicateBE archive |
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