pksensi: Global Sensitivity Analysis in Physiologically Based Kinetic Modeling

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters.

Version: 1.1.5
Depends: R (≥ 3.5)
Imports: ggplot2, data.table, deSolve, dplyr, getPass, magrittr, reshape
Suggests: knitr, rmarkdown, testthat
Published: 2020-02-05
Author: Nan-Hung Hsieh ORCID iD [aut, cre], Brad Reisfeld [aut], Weihsueh A. Chiu ORCID iD [aut]
Maintainer: Nan-Hung Hsieh <nhsieh at>
License: GPL-3 | file LICENSE
NeedsCompilation: no
Materials: NEWS
CRAN checks: pksensi results


Reference manual: pksensi.pdf
Vignettes: Acetaminophen-PBPK model
One-compartment PK model
Package source: pksensi_1.1.5.tar.gz
Windows binaries: r-devel:, r-devel-gcc8:, r-release:, r-oldrel:
OS X binaries: r-release: pksensi_1.1.5.tgz, r-oldrel: pksensi_1.1.5.tgz
Old sources: pksensi archive


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