RNOmni: Rank Normal Transformation Omnibus Test

Genetic association tests that use the rank-based inverse normal transformation (INT). These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not. Moreover, INT-based tests dominate standard linear regression in terms of power. INT-based tests may be classified into two types: tests that directly transform the phenotype (D-INT) and tests that transform phenotypic residuals (I-INT). Our omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach.

Version: 0.7.1
Depends: R (≥ 3.2.2)
Imports: abind, foreach, plyr, Rcpp
LinkingTo: Rcpp, RcppEigen
Suggests: cowplot, ggplot2, knitr, reshape2, rmarkdown
Published: 2019-04-28
Author: Zachary McCaw [aut, cre]
Maintainer: Zachary McCaw <zmccaw at g.harvard.edu>
License: GPL-3
NeedsCompilation: yes
CRAN checks: RNOmni results


Reference manual: RNOmni.pdf
Vignettes: Rank Normal Omnibus Association Test
Package source: RNOmni_0.7.1.tar.gz
Windows binaries: r-devel: RNOmni_0.7.1.zip, r-release: RNOmni_0.7.1.zip, r-oldrel: RNOmni_0.7.1.zip
macOS binaries: r-release: RNOmni_0.7.1.tgz, r-oldrel: RNOmni_0.7.1.tgz
Old sources: RNOmni archive


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