nlmixr: Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 1.1.1-9
Depends: R (≥ 3.5)
Imports: Rcpp (≥ 0.12.3), brew, parallel, methods, ggplot2, memoise, Matrix, n1qn1, fastGHQuad, cli, RcppArmadillo (≥ 0.5.600.2.0), RxODE (≥ 0.9.1-9), nlme, magrittr, tidyr, generics, flextable, stringr, yaml
LinkingTo: dparser (≥ 0.1.8), RxODE (≥ 0.9.1-3), RcppEigen (≥, lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0)
Suggests: knitr, rmarkdown, dplyr, tibble, data.table, lbfgsb3c, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf, Rvmmin, broom.mixed, dotwhisker, officer, pkgdown, gridExtra, xpose, lotri, rex, minqa, lattice, digest, sys, crayon, lbfgs, dparser, vpc (≥ 1.0.0), huxtable
Published: 2020-06-22
Author: Matthew Fidler ORCID iD [aut], Yuan Xiong [aut], Rik Schoemaker ORCID iD [aut], Justin Wilkins ORCID iD [aut], Richard Hooijmaijers [aut], Teun Post [aut], Wenping Wang [aut, cre], Robert Leary [ctb], Mirjam Trame [ctb], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Bill Denney ORCID iD [ctb], Daniel C. Dillon [ctb], Katharine Mullen [cph], Ben Goodrich [ctb]
Maintainer: Wenping Wang <wwang8198 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
Citation: nlmixr citation info
Materials: NEWS
CRAN checks: nlmixr results


Reference manual: nlmixr.pdf
Package source: nlmixr_1.1.1-9.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release: nlmixr_1.1.1-9.tgz, r-oldrel: nlmixr_1.1.1-9.tgz
Old sources: nlmixr archive

Reverse dependencies:

Reverse suggests: ggPMX


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