A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.
| Version: | 1.0.0 |
| Depends: | R (≥ 3.6) |
| Imports: | nlme, RLRsim, stats |
| Suggests: | rmarkdown, knitr |
| Published: | 2020-12-03 |
| Author: | Zhengyang Zhou [aut] Sydney Manning [aut, cre] Chao Xing [aut] Hung-Chih Ku [aut] |
| Maintainer: | Sydney Manning <sydneymanning at my.unthsc.edu> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| CRAN checks: | GEVACO results |
| Reference manual: | GEVACO.pdf |
| Vignettes: |
GEVACO Introduction |
| Package source: | GEVACO_1.0.0.tar.gz |
| Windows binaries: | r-devel: GEVACO_1.0.0.zip, r-release: GEVACO_1.0.0.zip, r-oldrel: GEVACO_1.0.0.zip |
| macOS binaries: | r-release: GEVACO_1.0.0.tgz, r-oldrel: GEVACO_1.0.0.tgz |
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