precautionary: Safety Diagnostics for Dose-Escalation Trial Designs

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020b), "Retrospective analysis of a fatal dose-finding trial" <arXiv:2004.12755> and (2020c) "What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design" <arXiv:2012.05301>.

Version: 0.2-1
Depends: magrittr, escalation, data.table, R (≥ 3.5.0)
Imports: methods, dplyr, rlang, stringr, knitr, kableExtra
Suggests: rmarkdown, bookdown, tufte, testthat, lattice, latticeExtra, dtpcrm
Published: 2021-01-12
Author: David C. Norris ORCID iD [aut, cre, cph], Markus Triska [ctb]
Maintainer: David C. Norris <david at>
License: MIT + file LICENSE
NeedsCompilation: no
Materials: NEWS
CRAN checks: precautionary results


Reference manual: precautionary.pdf
Vignettes: FDA proactive clinical hold
Introduction to package 'precautionary'
Universal safety schematics via DTP
Package source: precautionary_0.2-1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release: precautionary_0.2-1.tgz, r-oldrel: precautionary_0.2-1.tgz
Old sources: precautionary archive


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