A streamlined tool for eplet analysis of donor and recipient HLA (human leukocyte antigen) mismatch. Messy, low-resolution HLA typing data is cleaned, and imputed to high-resolution using the NMDP (National Marrow Donor Program) haplotype reference database <https://haplostats.org/haplostats>. High resolution data is analyzed for overall or single antigen eplet mismatch using a reference table (currently supporting 'HLAMatchMaker' <http://www.epitopes.net> versions 2 and 3). Data can enter or exit the workflow at different points depending on the user's aims and initial data quality.
| Version: | 0.1.0 |
| Depends: | R (≥ 3.5.0) |
| Imports: | devtools, usethis, tidyverse, dplyr, reshape2, schoolmath, tibble, stringr, purrr, tidyr, utils, readr, here, readxlsb |
| Suggests: | knitr, rmarkdown |
| Published: | 2021-04-13 |
| Author: | Joan Zhang [aut, cre], Aileen Johnson [aut], Christian P Larsen [cph, aut] |
| Maintainer: | Joan Zhang <joan.zhang at emory.edu> |
| License: | MIT + file LICENSE |
| NeedsCompilation: | no |
| CRAN checks: | hlaR results |
| Reference manual: | hlaR.pdf |
| Vignettes: |
Imputation Eplet Mismatch |
| Package source: | hlaR_0.1.0.tar.gz |
| Windows binaries: | r-devel: hlaR_0.1.0.zip, r-release: hlaR_0.1.0.zip, r-oldrel: hlaR_0.1.0.zip |
| macOS binaries: | r-release (arm64): hlaR_0.1.0.tgz, r-release (x86_64): hlaR_0.1.0.tgz, r-oldrel: hlaR_0.1.0.tgz |
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