nlmixr: Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 2.0.4
Depends: R (≥ 4.0)
Imports: Rcpp (≥ 0.12.3), brew, parallel, lbfgsb3c, dparser, methods, ggplot2, rex, minqa, Matrix, n1qn1 (≥ 6.0.1-10), fastGHQuad, RxODE (≥ 1.0.6), nlme, magrittr, backports, symengine
LinkingTo: dparser (≥ 0.1.8), RxODE (≥ 1.0.0-0), RcppEigen (≥, lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0), RcppArmadillo (≥ 0.5.600.2.0)
Suggests: Deriv, Rvmmin, broom.mixed, crayon, knitr, data.table, devtools, digest, dotwhisker, dplyr, expm, flextable, ggtext, patchwork, gridExtra, huxtable, lattice, lbfgs, lotri, madness, matrixcalc, nloptr, officer, pkgdown, reshape2, rmarkdown, testthat, tidyr, ucminf, vpc (≥ 1.0.0), xgxr, yaml, xpose, generics, tibble, checkmate, cli, qs, covr, forecast, latticeExtra
Published: 2021-04-17
Author: Matthew Fidler ORCID iD [aut], Yuan Xiong [aut], Rik Schoemaker ORCID iD [aut], Justin Wilkins ORCID iD [aut], Wenping Wang [aut, cre], Robert Leary [ctb], Mason McComb ORCID iD [aut], Mirjam Trame [ctb], Teun Post [ctb], Richard Hooijmaijers [aut], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Daniel C. Dillon [ctb], Katharine Mullen [cph], Ben Goodrich [ctb]
Maintainer: Wenping Wang <wwang8198 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
Citation: nlmixr citation info
Materials: NEWS
In views: DifferentialEquations
CRAN checks: nlmixr results


Reference manual: nlmixr.pdf
Package source: nlmixr_2.0.4.tar.gz
Windows binaries: r-devel:, r-devel-UCRT:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): not available, r-release (x86_64): nlmixr_2.0.4.tgz, r-oldrel: nlmixr_2.0.4.tgz
Old sources: nlmixr archive

Reverse dependencies:

Reverse imports: xpose.nlmixr
Reverse suggests: ggPMX


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